What is Prevagen?

Prevagen is a brand of OTC dietary supplements available as once-daily oral capsules or chewable tablets. Each supplement contains 50 mcg (2,000 units) of vitamin D3 and different amounts of apoaequorin, a protein that is found in certain types of jellyfish. Three different doses of Prevagen contain 10 mg, 20 mg, or 40 mg of apoaequorin.

Decreased cognitive function is joint with age and may include memory loss. Pharmacists can support brain health and also the well-being of elderly people in the community by understanding the age-related changes in cognitive function and the dietary supplements which are available to promote healthy brain activity.

Does Prevagen Work?

This memory supplement may work for some. However, it is recommended to use a dietary supplement that has ingredients such as citicoline, Bacopa Monnier, phosphatidylserine, vitamin B complex, N-Acetyl L-Tyrosine, L-theanine, and many other already proven ingredients. It is advisable to use dietary supplements that contain the tested ingredients.

Apoaequorin, the main component of Prevagen, has not been thoroughly studied and needs further research. You can’t say that it does not work. Many customers are happy with the benefits of Amazon and other platforms.

Quincy Bioscience explains the working mechanism and action of Prevagen. These proteins are depleted with age and brain cells become more vulnerable to damage.

Without further explanation or specific scientific evidence, vague statements such as "cell-supporting activities" show that it is a fraud. None of the studies published on the Prevagen website tells us how the product works. So, as we know, it contains a unique protein with excellent properties.

How Prevagen Works?

There are various chemicals that affect the human brain and memory. Some of these chemicals are acetylcholine, norepinephrine, calcium, and amyloid-beta protein. According to some experts,  the cell's protein, calmodulin, can regulate calcium levels in the brain to reduce age-related mental disorders such as poor concentration. Improves cognitive ability and memory function.

Apoaequorin is structurally similar to calmodulin, so its benefits are touted. Both have the same structure but improve mental performance by increasing concentration and cognitive ability. Apoaequorin can also bind to calcium in the laboratory and lower its levels. 

However, some experts and pharmacologists say it is safe for oral use as it is slowly degraded to amino acids by hydrolysis. However, most digestive enzymes break down proteins, so you cannot get enough apoaequorin in your brain without experiencing side effects or side effects after oral intake.

Because of these factors, we can conclude that apoaequorin is more likely to have neuroprotective effects when injected directly into the brain. However, this is not possible because of the size which is 22,885 Dalton, and the inability to cross the blood-brain barrier.

This protein cannot protect neurons, but there are ways to prevent them from being damaged by lifestyle changes, such as lifestyle changes.

Reduces and limits physiological stress. Manage blood sugar levels. Exercise regularly to avoid social isolation. Get the best sleep you need. You can’t say that there are no such supplements to protect your brain and improve cognition. According to several published studies, L-Tyrosine, Vitamin B6, fish oil supplements, folic acid, resveratrol, caffeine, phosphatidylserine, acetyl L-Carnitine, ginkgo, Bacopa Monnie, and many other ingredients can protect the brain and improve memory at a basic level. It helps  All of these ingredients are included in Prevagen that's why we recommend it.

Prevagen Review

Ingredients

Vitamin D

Vitamin D is a nutrient that our body produces when exposed to the sun. According to some studies, taking vitamin D supplements can help avoid various chronic illnesses, but none are definitive. The only thing researchers are convinced of is that vitamin D is essential to help our body properly absorb and use calcium, a mineral needed for healthy bones.

Based on this and other similar studies, some OTC manufacturers recommend using vitamin D to prevent memory loss. However, no studies have shown that taking this supplement regularly can prevent memory loss.

Apoaequorin

Neuronal calcium dysregulation has been shown to contribute to age-related learning and memory disorders. Apoaequorin is a calcium-binding protein that can be found in the glowing jellyfish (Aequorea victoria) and it also has a unique component of Prevagen. Calcium-binding proteins play an essential role in regulating intracellular calcium homeostasis, which is an essential part of neuronal function. 

Declines related to aging in intracellular calcium-binding protein expression and concentration, as well as changes in their distribution throughout the central nervous system, maybe the cause of the cognitive decline and increased susceptibility to neuronal damage and death. It is suggested that there is. Given the role of calcium-binding protein in the pathophysiology of age-related neurocognitive decline, the administration of exogenous apoaequorin may be beneficial.

One of the problems with putting apoaequorin in capsules or tablets is that it may have absorption problems. When you take protein orally, the stomach and pancreas immediately start working together to break down and digest the protein. This makes the development of successful protein-based oral drugs so tricky that many of these drugs are injection-only.

Prevagen is a dietary supplement on the market, so you don't need to take a test to see exactly how it works in your body after ingestion. 

Because of this, apoaequorin can be broken down in the stomach without getting absorbed, leading to the question of how it can reach the brain to help with memory loss. From this, you can now say that Prevagen is just vitamin D linked to an unknown ingredient called apoaequorin. Vitamin D has no notable nootropic effect, so the rest of the review will focus solely on apoaequorin.

This is very unusual. The best nootropic supplements that promise to improve memory, support brain health, and improve overall cognitive function combine several different nootropics, each with a different mechanism of action. 

In general, the best nootropics increase the production of neurotransmitters, reduce stress and improve blood circulation.  A group of proven ingredients is used to do this. That is why Quincy Bioscience is sure that apoaequorin is a wonderous remedy that can essentially reverse memory loss and possibly help people avoid Alzheimer's disease and dementia. You won’t be needing any other nootropics to improve your memory.

Safety

The unique ingredient in Prevagen is Apoaequorin which has undergone extensive safety testing for toxicity and allergenicity. According to human clinical studies, apoaequorin was well tolerated for up to 90 days. Studies on animal safety have shown that apoaequorin can be safely taken orally at doses well more than the recommended daily dose (4,000 to 16,000 times the recommended daily dose of Prevagen Regular Strength) without side effects. 

Apoaequorin is not a known allergen and is unlikely to cross-react with a known allergen. In another safety study, apoaequorin showed a digestibility profile similar to other non-allergic food proteins. It was not at significant risk of allergic responsiveness when taken orally.

Evidence of the use of prevalence is limited and flawed. In 2016, Quincy Bioscience published a small study comparing 10 mg of apoaequorin per day with placebo (tablets without medication) for 90 days. All study participants reported memory problems themselves, but none had severe memory loss, such as Alzheimer's disease or dementia.

At the end of the study, those who took apoaequorin scored higher on several tests that measured overall memory than those who took a placebo. The study's authors found that the differences between the two groups were significant, and Quincy Bioscience, who sponsored the study, used these results to support Prevagen's claim.

However, there are some problems or unclear deductions with this study. First of all, there were over 200 participants, and it was only run for 90 days. This number is less than what is typically needed to prove that the drug is effective for the general public. Also, conducting a study for only 90 days means that the long-term safety or efficacy of Prevagen is unknown.

Another issue with this study is the type of test the researcher used to test his memory. None of the cognitive assessments used in this study are standard tests used by healthcare providers to screen and diagnose amnesia. Using non-standard tests makes it difficult to interpret the results, so it is impossible to determine how effective Prevagen is.

Recommendations

Prevagen's proceedings and settlement agreement are convincing that dietary supplement regulations need to be urgently reviewed to reduce public health risks resulting from the health promotion of dietary supplements that are not backed by solid science. Provide some evidence. Using the new nutritional components of Section 8 of DSHEA as a template, the wording proposed for this revision is shown in bold below as an appendix to Section 6 Nutrition Support Statement, Section (B) of 21 USC. increase. § 343 (r) (6).

Dietary supplement manufacturers are fit for the benefits they need because such statements are accurate and not misleading. Meets strong standards of scientific evidence. They were collected by the Food and Drug Administration for review and approval at least 75 days prior to the introduction into interstate trade.

This revision means. "The Food and Drug Administration has not evaluated this statement. .. "In Section 6, paragraph (C) is obsolete and should be removed from 21U.SC. Section 343 (r) (6).

FDA is the" Important Scientific Consensus Standards "(SSA). It should be used to assess the credibility of the dietary supplement manufacturer's remarks. 

The SSA needs an agreement between qualified medical professionals that are all publicly available scientific evidence supports the allegations. This is far more powerful than the current standard of" competent and credible scientific evidence "that Quincy used to support Prevagen's structural/functional claims.

To help the FDA become an active dietary supplement regulator, its premarket role is through a new royalties program modelled after the 1992 Prescription Drug Administration (PDUFA). It may be funded. Like the Securities and Exchange Commission's (SEC) registration fee system, the FDA must configure royalties like non-negotiable taxes.  

Using the SEC and its pricing structure as a model and having an equal business relationship (against potential imprisonment) sets goals and expectations and influences the FDA's pre-approval decision-making. 

Pros and Cons

Pros
  • It is the best-selling nootropic dietary supplement.
  • Prevagen reviews are positive from all those who have used it. 
  • The size of the pill is small which is why it is easy to swallow.
  • It is a third-party tested nootropic drug-a plus for this brand.
  • It does not contain harmful ingredients, so that you can use it with confidence.
Cons
  • The stacks of Prevagen are expensive as compared to other products of a similar type. 
  • The active ingredient has less scientific evidence than the proven and well-studied ingredients.
  • A proceeding against this company is pending. FTC claims to have made false advertisements.